Prohibition that Fell into Permitted Food

Hello, I know that the Halacha is that if a prohibition falls into permitted food, the dish is allowed if there is sixty times more permitted food than the prohibited substance. However, I have not seen any reference to the time it takes for the prohibition to mix with the permitted food: it depends on whether the prohibition is liquid or not, and whether the permitted food is liquid or not, and it also depends on the temperature of the dish. It seems obvious to me that blood or sauce of the prohibition will mix faster in boiling soup than a piece of meat in a dish containing large pieces of apples or cabbage, and the dish is not on a low flame. In any case of nullification in sixty, should all these factors be considered, or can it be permitted in any case where the amount of permitted food is sixty times the amount of the prohibition? If it indeed depends on all this, I would appreciate sources. Thank you

Hello,

As long as there is sauce in the dish, and the prohibition falls into the sauce or into pieces submerged in the sauce, the sauce evenly mixes the prohibition throughout the dish, and it is sufficient if there is sixty times the amount of the prohibition in the entire dish.

However, if the prohibition falls on a piece protruding from the sauce, and that piece is not immediately mixed into the sauce, the piece initially absorbs the prohibition, and if it does not have sixty times the amount of the prohibition itself, it becomes prohibited, even though the entire pot has sixty times the amount of the prohibition.

In such a case, if milk falls on a protruding piece of meat and the piece does not have sixty times the amount of milk, not only does the piece become prohibited, but the entire pot becomes prohibited if it does not have sixty times the amount of the entire piece of meat that is prohibited.

Shulchan Aruch, Yoreh De'ah, Siman 92, Se'if 2